Q-Sense Instruments and Accessories

Interfaces and molecular interactions

Lasing, S.A. represents Q-SENSE who develops and markets research instruments based on the patented Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) technology. The instruments determine, in situ and in real time, the mass and structure of molecular layers that form on the sensor. Simultaneous measurements of both mass and structural properties allow a thorough understanding of the molecular adsorption and interactions under a variety of experimental conditions.

The Q-Sense Omega Auto is an automated and fully integrated QCM-D system.

Vídeo: Principle of QCM-D technology, and highlight important application areas.

Vídeo: How Multi-Parametric SPR differs from traditional SPR?

Lasing, S.A. represents BIONAVIS. SPR Navi™ instruments are the only SPR instruments on the market using the newest technique – the MultiParametric SPR (MP-SPR). Multi-Parametric does not only measure molecular interactions, but also properties of thin and thick layers. While others measure only the angular position of the SPR peak, we measure the whole SPR curve. This enables you to measure chips coated with other metals than gold, to measure both thin and thick samples, and many more. In fact, it can even distinguish a buffer change. Moreover, our instruments can be equipped with additional lasers with various wavelengths. This offers you the unique possibility to work also with absorbing samples or to measure refractive index (RI) when thickness is not known precisely and vice versa.

QCM-D

SPR

Applications

Videos

  1. •Biomaterials

  2. •Cell & Molecular Biology

  3. •Cellulose

  4. •Cleaning & Detergents

  5. •Energy

  6. •Environmental

  7. •Lipids

  8. •Nanoparticles

  9. •Pharmaceuticals

  10. •Polymers

  11. •Proteins

  12. •Surfactants

Applications in Life Science

Vídeo: Q-sense Omega Auto Animation

With PureKinetics™ feature for high quality kinetics, MP-SPR is a powerful and sensitive tool for direct measurements of small molecules. 

MP-SPR helps you to measure biomembrane interaction kinetics as well as underlying structural changes.

Whether you develop metal, silica, polymer nanoparticles or work with DNA polyplexes, liposomes, viruses or microvesicles, MP-SPR is an excellent choice for drug delivery studies - from real-time targeting studies to real-time internalization with the same instrument. 

MP-SPR enables to move from drug-target measurements, through drug-membrane interactions all the way to drug-cell interactions. Differentiate internalization from permeation in real-time and label-free. Study cell attachment on different coatings.

Antibody-antigen interaction affinity and kinetic measurements can be performed in diverse liquids including complex liquids such as serum or saliva.

MP-SPR can be combined with electrochemistry to measure catalytic interactions, electroswitching surfaces and also to develop electrochemical biosensors.  

From nanoparticle-based competitive assays through electrochemical sensors to direct assays, MP-SPR shows all the steps of your assay may you develop it on top of glass, polymer, silica or metal surfaces! More...

MP-SPR works also with gas samples - from 2 dalton hydrogen up to vapours. More.. 

MP-SPR measures interactions on polymers up to 5 µm thick, which makes it the most sensitive label-free technique for biomaterial interaction studies and layer characterization. Therefore, MP-SPR also helps with formulations for controlled drug release, novel coatings for cell and tissue engineering as well as industrial coatings.

Applications in Material Science

Solar cells, displays, food packaging, anticorrosive, antimicrobial, antireflective functional coatings - MP-SPR helps to reduce the coating thickness while maintaining the functionality. MP-SPR allows measurement of interactions as well as thickness and complex refractive index of ultrathin metal coatings from 3Å to 100 nm and more...

MP-SPR is an ideal tool for development of graphene coatings for biosensing, gas sensing, composites, displays and other applications. MP-SPR measures thickness of graphene from single monolayer and also its changes and interactions with molecules in real-time. 

MP-SPR measures thickness of ultrathin films of metals, oxides and ceramics up to 100 nm. It can be applied to a wider range of applications from semiconductors to biological implant coatings. Refractive index, moisture interaction and antifouling can be characterized too.

THIN SOLID FILMS

SOFT MATERIALS

MP-SPR can measures interactions to hydrogels from ultrathin films up to 5 µm, which makes it the most sensitive label-free technique for biomaterial interaction studies and layer characterization. For example measurement of protein adsorption to polymer without water artefacts and real-time polymer brush collapse.

Green plastics, food additives, drug delivery, implants, composites, paints, organic solar cells, printed electronics, biosensors,... Nanocellulose  can be used in different applications by selecting a favourable characteristics of the material. MP-SPR is used by researchers around the world to develop nanocellulose for different applications.

MP-SPR can be combined with electrochemistry to measure interactions and conformation changes under different electric potential, pH and temperature. MP-SPR can be also used to develop electrochemical biosensors or to characterize electrically-induced reactions such as electropolymerization or corrosion.

SENSING

From nanoparticle-based competitive assays through electrochemical sensors to direct assays, MP-SPR shows all the steps of your assay may you work with glass, polymer, silica or metal surfaces!

MP-SPR works also with gas samples, and is exremely sensitive for gas detection. Even hydrogen with molecular weight of 2 daltons can be measured. Applications for example in gas storage, detection and swelling of films due to organic vapors. 

Whether you develop metal, silica, polymer or other nanoparticles, MP-SPR is an excellent choice for nanoparticle characterization. Get your before and after images with TEM, SEM or AFM. See the dynamics of self-assembly, targeting, release or internalization in real-time with MP-SPR!

PHARMACEUTICALS

BIOSENSOR DEVELOPMENT

BIOMATERIALS AND COATINGS